As a Graduate and Consultant in the Business Tax Advisory (Financial Services) team, I provided tax advice and tax compliance services to organisations in the banking and capital markets, wealth and . Tina Huang. Natl Acad. C. Posth, H.Y., A.G., A.B.R., W.H. This was achieved through collaboration with local curators and scientists from the countries where the skeletal material is preserved and who are listed among the authors of this study. Materials provided by Max Planck Institute for Evolutionary Anthropology. Fourth, we extend the finding of a large-scale genetic turnover as early as 14ka in central and western European hunter-gatherers associated with multiple techno-complexesFedermesser, Azilian and other Final Palaeolithic groups4despite considerable technological continuity with the preceding late Magdalenian. Tina Huangis a data scientist currently working at a large FAANG enterprise. No need to do it alone our community of learners and instructors is there for you. This is perfect for those of us who haven't a clue what to expect from data science - SQL portion - interviews. Fu, Q. et al. One of my favorite videos of her is where she talks about the resume that got her an entry-level data science job. 4 and Supplementary Data 3.C). After the LGM, the Epigravettian culture was widespread in southern andsoutheastern Europe. Adapted from https://doi.org/10.5281/zenodo.5903165 (CC BY 4.0). Then we merged the genotypes from different libraries of the same individual, by randomly picking alleles from available genotype calls, using a custom script. Its the complexity of product development, with all of its moving parts, that makes data immensely powerful. Here, data really gets to shine, in that its both the source of truth and the driver of insights. The cleaned reads with base quality and mapping quality over 30 were piled up with mpileup in SAMtools 1.373 on the 1240k targeted sites. Other proposed climatic refugia for human survival during this period are the Italian peninsula, the Balkans and the southeastern European Plain, but the actual genetic contribution of populations from these regions to post-LGM Europeans is highly debated11,12,13. AMAZING COURSE! To mark the occasion, rather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. 14, evac045 (2022). What is Connection Map in Data Visualization? Her YouTube channel is dedicated to data and computer science, including how to educate yourself in these topics. Look here to get updated on my recent favourite books, animes, filming equipment and more! Dotted lines delimit geographic regions described in the text. Write a sharp and effective resume in minutes and get noticed by employers. Curr. Curr. Hajdinjak, M. et al. Nature 524, 216219 (2015). In conclusion, our study reveals that western and southwestern Europe served as climatic refugia for the persistence of human groups during the coldest phase of the last Ice Age whereas populations in the Italian peninsula and the eastern European plain were genetically overturned, challenging the role of these regions as glacial refugia for humans. The x-axes report the geographic regions as divided in Fig. Data mining is the process of finding patterns in large amounts of data. Tina Huang, a data scientist currently working at a FAANG (Facebook, Amazon, Apple, Netflix, and Google Alphabet) company. Both of these ancestries carry a genetic component distantly related to the Goyet Q116-1 individual dated to 35ka, with the Iberian individual also showing an affinity to the Villabruna cluster4,14. Dashed lines show the frequencies estimated for the indicatedpresent-day 1000 GenomesProject populations (CEU, Utah residents of northern and westernEuropean ancestry; GBR, British; IBS, Spanish;TSI,Tuscan)37. Tina started her YouTube channel in 2020. Tina Huang Popularity . During this time agriculture and a sedentary lifestyle spread from Anatolia to Europe. 6 and Supplementary Fig. USA 117, 1279112798 (2020). Extensive farming in Estonia started through a sex-biased migration from the steppe. 17, 60 (2016). Jones, E. R. et al. Cosimo Posth, He Yu or Johannes Krause. The y axis shows the average of calibrated radiocarbon dates in thousands of years (kyr) (Supplementary Data 1.A). Maier, A. in The Central European Magdalenian 81180 https://doi.org/10.1007/978-94-017-7206-8_6 (Springer, 2015). This genetic signature is shared among individuals associated with the archaeologically defined Gravettian culture (3326ka) in central and southern Europe and seemingly disappeared after the Last Glacial Maximum4 (LGM). And if youre new to data science, check out the 365 Intro to Data and Data Science course. (Robert Rueda; Tina Saldivar; Lynne Shapiro; Shane Templeton; Houghton Mifflin Company Staff) 2022-112-4f84b - Ecologizr. Harris, K. & Nielsen, R. The genetic cost of Neanderthal introgression. Itchy Eyes and a Runny Nose? ), no. Provided by the Springer Nature SharedIt content-sharing initiative. 5 and Supplementary Information, section9). Olalde, I. W jednej z historii misiaczki za rad pewnej wydry zamieszkuj w tajemniczym domostwie. . Mounier, A. et al. Genome Biol. Charlton, S. et al. Nature 505, 8791 (2014). 6 Reasons We Just Cant Stop. (2023, March 1). The analysed genomes also show that the descendants of these Epigravettian inhabitants of the Italian peninsula spread across the rest of Europe about 14,000 years ago, replacing populations associated with the Magdalenian culture. Our capabilities include CNC machining, sheet metal Her code challenge was titled Bias-Explained by Quantitative Data. 12, 5425 (2021). Korlevi, P. et al. Nat. 27, 576582 (2017). This is . 1a, and the y-axes report time in thousand years before present (kBP). Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. Great content - Tina is all class and an excellent instructor. Li, H. et al. Key, F. M. et al. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers. Notes 9, 88 (2016). Adv. Individuals with libraries showing signs of contamination were further tested using PMD-filtered bam files. Tina Huang Data Scientist. Tina Huang is a well-known data scientist who has over 10 years of experience on YouTube and has previously worked at a FAANG organization. Int. CNRS, MNHN, Universit de Paris Cit, Muse de lHomme, Paris, France, PALEVOPRIM Lab UMR 7262 CNRS-INEE, University of Poitiers, Poitiers, France, Centre de Valorisation des Collections Scientifiques, Universit de Poitiers, Mignaloux Beauvoir, France, Muses de PoitiersVille de Poitiers, Poitiers, France, Departamento de Geologa, Facultad de Ciencia y Tecnologa, Universidad del Pas Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Leioa, Spain, Sociedad de Ciencias Aranzadi, Donostia-San Sebastian, Spain, Centro UCM-ISCIII de Investigacin sobre Evolucin y Comportamiento Humanos, Madrid, Spain, Institute of Archaeology, University of Rzeszw, Rzeszw, Poland, Foundation for Rzeszw Archaeological Centre, Rzeszw, Poland, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA, Department of Psychiatry, Harvard Medical School, Boston, MA, USA, Groninger Instituut voor Archeologie, Groningen University, Groningen, The Netherlands, Institute of Archaeology and Ethnology, Polish Academy of Science, Pozna, Poland, Institute of History, Archaeology and Ethnography, Dushanbe, Tajikistan, ArchaeoZOOlogy in Siberia and Central AsiaZooSCAn, CNRSIAET SB RAS International Research Laboratory, IRL 2013, Institute of Archaeology SB RAS, Novosibirsk, Russia, Research Institute and Museum of Anthropology, Moscow State University, Moscow, Russia, Grupo de I+D+i EVOADAPTA (Evolucin Humana y Adaptaciones durante la Prehistoria) Departamento de Ciencias Histricas, Universidad de Cantabria, Santander, Spain, Borja Gonzlez-Rabanal,Ana B. Marn-Arroyo&Lawrence G. Straus, Instituto Internacional de Investigaciones Prehistricas de Cantabria (IIIPC), Universidad de Cantabria-Gobierno de Cantabria-Banco Santander, Santander, Spain, Departamento de Biologa de Organismos y Sistemas, Universidad de Oviedo, Oviedo, Spain, Quaternary Environments and Humans, OD Earth and History of Life, Royal Belgian Institute of Natural Sciences, Brussels, Belgium, Caroline Polet,Ivan Jadin&Sbastien Villotte, Muses Royaux dArt et dHistoire, Bruxelles, Belgium, Institute of Historical Research, University of Girona, Catalonia, Spain, Joaquim Soler,Neus Coromina&Isaac Ruf, INRAP/UMR 8215 Trajectoires 21, Paris, France, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA, Department of Anthropology, University of New Mexico, Albuquerque, NM, USA, GoArchPal-GoArchon, Viville sous-les-Cotes, France, Archologie & Mnzkabinett, Universalmuseum Joanneum, Graz, Austria, Museum Das Dorf des Welan, Wllersdorf-Steinabrckl, Austria, Department of Humanities, University of Ferrara, Ferrara, Italy, National Museum of Antiquities, Leiden, The Netherlands, Faculty of Archaeology, Leiden University, Leiden, The Netherlands, Biogeology, Department of Geosciences, University of Tbingen, Tbingen, Germany, Unit de Recherches Art, Archologie Patrimoine, Universit de Lige, Lige, Belgium, I.U. Contrary to West Siberian hunter-gatherers, Tutkaul 1 does not carry an extra eastern Eurasian ancestry, but shows affinity to Iranian Neolithic farmers and some younger populations from Iran and the Turan region (Supplementary Data 2.L). ADS The f4-statistics were calculated by qpDstat 755 with parameter f4 mode: YES, with the Mbuti.DG population from Africa used as outgroup in all f-statistics analyses. 276, 107319 (2022). In the MDS plot (Fig. 10, 552010 (2019). The admixture graph shows that the Bacho Kiro IUP group (n=3) shares ancestry with multiple early modern human lineages2 (Supplementary Information, section7), and that the more than 45,000-year-old Zlat k genome1 is the most deeply divergent non-African lineage sequenced to date (Extended Data Fig. ScienceDaily. Considering a freshwater reservoir signal in the upper Volga region making radiocarbon dates on human remains appear up to about 500 years older than their true age44, there could be an interval of more than 1,000 years between the first evidence of admixture in central European hunter-gatherers with Sidelkino ancestry and eastern European hunter-gatherers with Oberkassel ancestry. Shes currently at Microsoft. Ace the SQL part of any data science job interview and get hired. She graduated with a degree in Computer Science and Applied Math. The sex of each individual was determined by the ratio of sequencing coverages on sex chromosomes versus autosomes (Supplementary Data 1.C). The hunter-gatherers were grouped based on their geographic origins and dates (Supplementary Information, section5). Greater San Diego Area. All Rights Reserved. "Presumably, these people came from the Balkans, arrived first in northern Italy around the time of the glacial maximum and spread all the way south to Sicily.". Libraries showing a mitochondrial or nuclear contamination rate over 10% were considered substantially contaminated whereas those between 5 and 10% were considered marginally contaminated and were treated differently (details are provided in Supplementary Information, section3). This broadly distributed ancestry (the Oberkassel cluster (also known as WHG)) is most closely related to an Epigravettian-associated individual from northwestern Italy, suggesting that its expansion into continental Europe might have started from the westand not the eastside of the Alps. Shes the founder of Coding Black Females, a nonprofit with the aim to provide opportunities for Black female developers to develop themselves, meet familiar faces, network, receive support, and build relationships through having regular meetups., Check out the Coding Black Females website. Have any problems using the site? Tina Huang. The mapped reads from the same individual and library set-up were merged and duplications were removed with DeDup. and JavaScript. ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. Lazaridis, I. et al. Lazaridis, I. et al. Interviewed Taiwanese designers and analyzed the interview data. Commun. In addition, our phylogeographic analysis points to northeastern Italy as the possible entry point of the Epigravettian-associated gene pool in the Italian peninsula. Where it all started :) I make weekly videos about self learning, practical productivity, and coding. First Name Tina. Life During Adulthood: Should One Get Credit Cards? The oldest individual in the Fournol cluster is Ormesson 2988 from northeastern France (31ka, Early/Middle Gravettian), whereasa Gravettian group from Goyet in Belgium (27ka, Late Gravettian) is found to be a mixture between the Vstonice and Fournol clusters. First, I like it because of how powerful (almost magical) it is in driving decisions. Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. Feb 2015 - Jun 20161 year 5 months. J. Archaeol. SQL for Data Science Interviews . This is also supported by f4-statistics of the form f4(Mbuti, Fournol 85; Sunghir, test), which are significantly positive for all the individuals included in the Vstonice cluster (Supplementary Data 2.B). Natl Acad. Proc. As long asyouget a exam score of 60% or above,youare eligible toreceive aCourse Certificate! A high-coverage genome sequence from an archaic Denisovan individual. About me. The data generated in this study enabled us to investigate genomic transformations of and interactions between Eurasian hunter-gatherers at high resolution (Extended Data Fig. 31, 24842493.e7 (2021). Her main topic is AI, exploring how it works and, most interestingly, how we increasingly interact with it in the world. Vallini, L. et al. Tina K. Sorensen. 5 Summary of ROH segments detected in Eurasian hunter-gatherers. Questions? Article Jagwire Europe - Fevacom NV . Int. 2. Rohrlach, A. Sikora, M. et al. First up is the MIT researcher and YouTuber Jordan Harrod. Brunel, S. et al. Her advice appears very solid, and she knows about the difficulties and barriers students are faced often when preparing for job interviews. & Posth, C. Latest trends in archaeogenetic research of west Eurasians. Follow a proven methodology, discover how to avoid common mistakes and impress employers as the best person for the job. The neighbour-joining tree was then reconstructed using the neighbour-joining method implemented in Ape 5.3 package104 of R 3.5.1. The detailed grouping of individuals shown with empty coloured circles is described in Supplementary Data 1.I. Notably, and contrary to the report by Fu et al.4, another Gravettian-associated population from centralwestern Europe (Goyet in Belgium, n=6 individuals) is both geographically and genetically intermediate between the Vstonice and Fournol clusters. Grizz, Panda i Lodomir maj rne charaktery, ale pomimo odmiennoci potrafi wspdziaa i wspiera si w kopotach. The human remains were processed in dedicated laboratories at the Max Planck Institute for the Science of Human History in Jena (Germany), University of Tbingen (Germany), University of Florence (Italy), Leiden University Medical Center (the Netherlands) and University of Tartu (Estonia). Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. In addition to her data science work, Tina has also created the popular popular game Code Wars. The purified products were amplified in multiple 100l reactions using Herculase II Fusion DNA Polymerase (Agilent) following the manufacturers specifications with 0.3M of the IS5/IS6 primers. In particular, the model achieves 96.21% for the validation and 96.47% for testing using the news aggregator data. Modern humans began to spread across Eurasia around 45,000 years ago but previous research showed that the first modern humans that arrived in Europe did not contribute to later populations. We built 1 to 8 single- and double-stranded genetic libraries for each individual and enriched them for human DNA on 1.24million single nucleotide polymorphisms6 (SNPs), which were then sequenced and yielded 0.04- to 7.64-fold coverage on average over the targeted SNPs. 4, 324333 (2020). Le palolithique suprieur en Italie. Madrid, Madrid, Spain. We provide five novel insights into the genomic history of hunter-gatherer populations over a time span of 30,000 years from the Upper Palaeolithic to the Neolithic. 2a). However, its formation, diffusion and interaction with contemporaneous hunter-gatherers from eastern Europe and their interplay with later expansions of Neolithic farmers from southeastern Europe are not well characterized. Ecol. A. Stoessel performed CT scanning and advised on sampling strategy. Proc. In addition to this general data science content, Tina teaches SQL . 14), most post-14ka individuals from western and central Europe fall close to the WHG cluster and those from eastern Europe close to the EHG cluster, whereas the Tutkaul 1 individual from central Asia falls close to the ANE-related group. & Vernot, B. Additional details are provided in SupplementaryInformation, section11 and SupplementaryTable 3. Patterson, N. et al. A software engineer who now works as a content creator full-time, Mayuko Inoue runs a YouTube channel dedicated to software engineering, working in the tech industry, and life in general. Citations 52. Overall, the literature suggests that Chinese Canadian students demonstrate high levels of achievement and that this academic success is associated with factors such as stronger feelings of ethnic identity, better English language skills in the family, Chinese . Herein, methane is upgraded through the photocatalytic oxidative coupling of methane (OCM) over a ternary Ag-AgBr/TiO 2 catalyst in a pressurized flow reactor. Nat. Y.H. Powered by Symplectic part of Digital Science . 4, 11 (2007). F4-statistics further support this view, revealing that Le Piage II is more closely related to the Fournol clusterthan the Vstonice cluster (f4(Mbuti, Le Piage II; Vstonice, Fournol 85)0, Z=6.58). & Steinrcken, M. Parental relatedness through time revealed by runs of homozygosity in ancient DNA. Become the most confident candidate in the room. We then removed samples with less than 0.04X coverage (calculated on the mappable, non-recombining region of the Y chromosome98) to avoid arbitrarily placing low-coverage samples at the root of major haplogroups. Genomic structure in Europeans dating back at least 36,200 years. 9 Graphical summary depicting the main genetic transformations in post-40 ka hunter-gatherers from Europe. The membrane was able to achieve FRR of 98.73 0.83 % after 4 cycles of filtration, indicating that anti-fouling properties have been enhanced. However, the genetic profile of contemporaneous Gravettian-associated individuals from western Europe remains unknown, as is their contribution to populations after the LGM. Pleistocene mitochondrial genomes suggest a single major dispersal of non-Africans and a Late Glacial Population turnover in Europe. She was not prepared for the complexity of a typical programming language. S. Shnaider received support from theRussian Science Foundation (no. 3b). The inferred pattern of short ROH (48 cM, visualized in blue) being common is in stark contrast to most later farmer populations, where the majority of individuals have no short ROH whatsoever (see101), and evidences small effective population sizes across West Eurasian hunter-gatherer groups. We applied ANGSD 0.93470 and hapCon71 for libraries from male individuals, and applied contamLD72 and a newly developed method that analyses contamination in ROH for female and male libraries (see Supplementary Information, section2 for a detailed description). Besides, the nucleolus is involved in a variety of cellular functions including cell cycle regulation and cellular stress response. B 370, 20130624 (2015). The PCA was carried out by smartpca in EIGENSOFT 6.0.1102, with modern individuals used for calculation and all the ancient individuals projected on the calculated PCs. Max Planck Institute for Evolutionary Anthropology. The mtDNA contamination was estimated by Schmutzi (--notusepredC --uselength)69 for all the libraries. Here we will provide you only interesting content, which you will like very much. is also supported by the Deutsche Forschungsgemeinschaft (DFG FOR 2237). and J.Krause performed or supervised genetic analyses. Fu, Q. et al. Paleogenomic evidence for multi-generational mixing between Neolithic farmers and Mesolithic hunter-gatherers in the Lower Danube Basin. USA 111, 22292234 (2014). Second, data-driven product development meshes very well with my own philosophy, commonly known as the 80/20 rule, where 80% of the results come from just about 20% of inputs. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Kristen Bell. Dr. Huang taught General Chemistry, Quantitative Analysis, and Instrumental Methods for eight years at . T.T., D.C. and E.A. The grouping of Epigravettian-associated populations is shown with the same colour in a. This often involves analyzing similar products to compare how they performed. As recommended, we analysed individuals with over 400,000 SNPs called on the 1240k panel101 and we called ROH longer than 4cM (Supplementary Data 3.B). Proc. Rev. Evol. www.sciencedaily.com/releases/2023/03/230301120846.htm (accessed March 4, 2023). Get the most important science stories of the day, free in your inbox. ), no. Enjoy maximum flexibility and forget about cramming against the clock. When expanded it provides a list of search options that will switch the search inputs to match the current selection. Details of the modelling are provided in Supplementary Data 3.C. Surprisingly, however, none of those pre-40ka individuals left substantial traces in the genetic makeup of present-day Eurasian populations1,2,6,7. Kotula, A., Piezonka, H. & Tergerger, T. The Mesolithic cemetery of Gro Fredenwalde (north-eastern Germany) and its cultural affiliations. 1 and 2). To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. Tina Huang Profile page. A genome sequence from a modern human skull over 45,000 years old from Zlat k in Czechia. On the basis of PCA and outgroup f3-statistics, the Neolithic Tutkaul 1 individual from Tajikistan is closely related to Upper Palaeolithic individuals from south-central Siberia (Afontova Gora 3 (AG3) and Malta 1), and roughly contemporaneous West Siberian hunter-gatherers (Tyumen and Sosnoviy), both carrying high proportions of ANE ancestry45 (Fig. The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). We further tested whether individuals included in the Vstonice and Fournol clusters share similar allele frequencies with the main representatives of those two clusters. The genetic prehistory of the Baltic Sea region. The pre-40kagroup and theFournol and Vstonice clusters are marked as shaded areas in different colours. We generated genome-wide sequencing data for 102 newly reported hunter-gatherers, and increased coverage for 14 previously published individuals4. 2, e190 (2006). Originally published at https://365datascience.com on October 1, 2020. Subsequently, I worked in bioinformatics for a year and then did my Master's in computer science (MCIT) at the University of Pennsylvania. Big Data, Data Mining, and Machine Learning (Jared Dean) . My name is Tina and I'm a data scientist and YouTuber. Dismiss. Instagram has an infinite scroll, and Uber has different options such as UberXL and Uber Pool. (black) or 3s.e.m. A Passive Flier. Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. The aligned sequences of all individuals with new genomic data reported in this study are available at the European Nucleotide Archive (ENA) under study accession number PRJEB51862. My main tasks: Modeling and developing the data structures and processes to optimize the loads of information, discovering insights and creating and maintaining reports. El Mirn has a significantly higher similarity to theVillabruna clusterthan Fournol 85 and Le Piage II, while the affinity to theVillabruna cluster in Le Piage II is not significantly higher than in Fournol 85 (Supplementary Data 2.D). The observation that post-14ka individuals from western and central Europe andalso from Britain41 carry a homogeneous genetic makeup instead of displaying repeated local admixtures with GoyetQ2 ancestry implies that the Oberkassel-ancestry profile was already largely formed before its dispersal. Radiocarbon 55, 163177 (2013). Inconsistent haplogroup assignments were manually verified as indicated24 (Supplementary Data 1.L). Think about some of your favorite apps today: Instagram, Uber, Facebook, and YouTube. Cassidy, L. M. et al. Its also hard to predict whats going to happen, but I hope its interesting to people who want to learn more about data science. Similarly, the SMS spam collection data achieves 99.20% for the validation and 99.10% for testing. 62, 3643 (2020). It can take several minutes for a query to complete, and if youre using a lot of data the whole table may be locked up. Unlike setting up a Premium subscription to our platform, for which you would be billed monthly or annually, acquiring individual courses requires a one-time payment only. The 3 Greatest Moments in science library uga hours History, Addicted to hills science diet adult small bites? The mitochondrial capture sequencing reads were cleaned by AdapterRemoval 2.2.0 to remove the adapters and reads with lengths below 30bp. 13). 724703 and no. 7 Admixture dates between Oberkassel/Villabruna and ANE ancestries in the oldest individuals from the Sidelkino cluster. Rivollat, M. et al. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Claim Author Page. van de Loosdrecht, M. et al. Nowadays, we take it for granted that these features exist, but the integrity of those products is, in fact, a labor of love. The oldest genomes carrying ancestries that derive primarily from the lineage leading to present-day Europeans are Kostenki 14 (from 37ka, with uncertain archaeological association from western Russia), Goyet Q116-1 (35ka, Aurignacian-associated from Belgium) and Bacho Kiro 1653 (35ka, probably Aurignacian-associated from Bulgaria)2,4,8.
Las Vegas New Year's Eve 2022 Fireworks,
Norwalk High School Baseball Roster,
When A Gemini Doesn T Talk To You,
Celebrities Who Live In Westport, Ct,
Why Did Driftwood Publick House Closed,
Articles T